You have a massive advantage over young guys, in that you've accumulated knowledge and life experience that they can only dream of, which a load of girls will find attractive. Yes it will be tough but then if you read a lot of younger guys posts, here on the forum, they're not dating hot girls after only doing five approaches, either!!
I'd avoid joining clubs unless you know the type of girls you like are attending as it could end up "hit and miss". I'd also avoid regularly hitting bars, as you say that it's a college town and you may get a reputation as the "craddle snatcher" if all you do is hang around on your own, chatting to young girls each weekend. By all means go with some friends, or if someone suggests going to a party there, then great, as you can approach girls as any guy would do. Cafes, coffee shops, juice bars, shops etc.. all offer great opportunities. Try experimenting with Indirect, Compliment and Direct openers, to see what works for you. Also as an older guy it's important to dress well; not like a guy ten years younger, but classic clothes (think Mr Clooney!
). Also try and have some knowledge about "younger trends". You don't want to start saying how you've "just bought XXXX's latest rap album which is dope" as you'll come across as sad and desperate but some background knowledge about the latest movies/music/culture..etc will help in conversation. As an older guy I love jazz and I'm always amazed by the number of younger women who like it. If you have any hobbies or interests, be passionate about them. They don't have to be "cool" or "hip", but women love a guy who's passionate about things in his life.
If you find yourself getting stuck on what t say try the trusted "Question-Statement-Question" approach. You ask her a question and then just make a statement on her answer i.e "You like Mexico, huh!?", "That reminds me, I once went to this great Tacco place in....blah blah" and just take it from there. Don't just ask question after question as it ends up in interview mode.
Try and listen to the recent Daygame podcast about Older guys which may be helpfull.
Good luck on your journey and keep us posted on your upcoming sucesses!